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Page 1
Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome.
Bostrom C, Yau SY, Majaess N, Vetrici M, Gil-Mohapel J, Christie BR. Bostrom C, et al. Neurosci Biobehav Rev. 2016 Sep;68:563-574. doi: 10.1016/j.neubiorev.2016.06.033. Epub 2016 Jun 23. Neurosci Biobehav Rev. 2016. PMID: 27345143 Review.
Fragile-X Syndrome (FXS) is the most common form of inherited intellectual disability and the leading genetic cause of autism spectrum disorder. ...One region of the brain that is significantly impacted by the loss of FMRP is the hippocampus, a structure that …
Fragile-X Syndrome (FXS) is the most common form of inherited intellectual disability and the leading genetic cause of …
Alterations in CA1 hippocampal synapses in a mouse model of fragile X syndrome.
Jawaid S, Kidd GJ, Wang J, Swetlik C, Dutta R, Trapp BD. Jawaid S, et al. Glia. 2018 Apr;66(4):789-800. doi: 10.1002/glia.23284. Epub 2017 Dec 23. Glia. 2018. PMID: 29274095 Free PMC article.
Fragile X Syndrome (FXS) is the major cause of inherited mental retardation and the leading genetic cause of Autism spectrum disorders. ...Deficits in the maturation and distribution of synaptic spines on dendrites of CA1 hippocampal neurons may play a …
Fragile X Syndrome (FXS) is the major cause of inherited mental retardation and the leading genetic cause of Autism spe …
A brain atlas of synapse protein lifetime across the mouse lifespan.
Bulovaite E, Qiu Z, Kratschke M, Zgraj A, Fricker DG, Tuck EJ, Gokhale R, Koniaris B, Jami SA, Merino-Serrais P, Husi E, Mendive-Tapia L, Vendrell M, O'Dell TJ, DeFelipe J, Komiyama NH, Holtmaat A, Fransén E, Grant SGN. Bulovaite E, et al. Neuron. 2022 Dec 21;110(24):4057-4073.e8. doi: 10.1016/j.neuron.2022.09.009. Epub 2022 Oct 5. Neuron. 2022. PMID: 36202095 Free PMC article.
Synapses with short protein lifetimes are enriched in young animals and in brain regions controlling innate behaviors, whereas synapses with long protein lifetimes accumulate during development, are enriched in the cortex and CA1 where memories are stored, and are preferen …
Synapses with short protein lifetimes are enriched in young animals and in brain regions controlling innate behaviors, whereas synapses with …
Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome.
Booker SA, Simões de Oliveira L, Anstey NJ, Kozic Z, Dando OR, Jackson AD, Baxter PS, Isom LL, Sherman DL, Hardingham GE, Brophy PJ, Wyllie DJA, Kind PC. Booker SA, et al. Cell Rep. 2020 Aug 11;32(6):107988. doi: 10.1016/j.celrep.2020.107988. Cell Rep. 2020. PMID: 32783927 Free PMC article.
Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing activity states is not fully understood. Here, we show increased axon initial segment length in CA1 …
Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitab …
Cell Type-Specific mRNA Dysregulation in Hippocampal CA1 Pyramidal Neurons of the Fragile X Syndrome Mouse Model.
Ceolin L, Bouquier N, Vitre-Boubaker J, Rialle S, Severac D, Valjent E, Perroy J, Puighermanal E. Ceolin L, et al. Front Mol Neurosci. 2017 Oct 20;10:340. doi: 10.3389/fnmol.2017.00340. eCollection 2017. Front Mol Neurosci. 2017. PMID: 29104533 Free PMC article.
Fragile X syndrome (FXS) is a genetic disorder due to the silencing of the Fmr1 gene, causing intellectual disability, seizures, hyperactivity, and social anxiety. ...We used the RiboTag approach and RNA sequencing to provide an exhaustive listing of genes wh …
Fragile X syndrome (FXS) is a genetic disorder due to the silencing of the Fmr1 gene, causing intellectual disability, …
Normal CA1 Place Fields but Discoordinated Network Discharge in a Fmr1-Null Mouse Model of Fragile X Syndrome.
Talbot ZN, Sparks FT, Dvorak D, Curran BM, Alarcon JM, Fenton AA. Talbot ZN, et al. Neuron. 2018 Feb 7;97(3):684-697.e4. doi: 10.1016/j.neuron.2017.12.043. Epub 2018 Jan 18. Neuron. 2018. PMID: 29358017 Free PMC article.
Silence of FMR1 causes loss of fragile X mental retardation protein (FMRP) and dysregulated translation at synapses, resulting in the intellectual disability and autistic symptoms of fragile X syndrome (FXS). Synaptic dysfunction hypotheses for how intellectu …
Silence of FMR1 causes loss of fragile X mental retardation protein (FMRP) and dysregulated translation at synapses, resulting in the intell …
Dysregulation of mTOR signaling in fragile X syndrome.
Sharma A, Hoeffer CA, Takayasu Y, Miyawaki T, McBride SM, Klann E, Zukin RS. Sharma A, et al. J Neurosci. 2010 Jan 13;30(2):694-702. doi: 10.1523/JNEUROSCI.3696-09.2010. J Neurosci. 2010. PMID: 20071534 Free PMC article.
Fragile X syndrome, the most common form of inherited mental retardation and leading genetic cause of autism, is caused by transcriptional silencing of the Fmr1 gene. The fragile X mental retardation protein (FMRP), the gene product of Fmr1, is an RNA binding …
Fragile X syndrome, the most common form of inherited mental retardation and leading genetic cause of autism, is caused …
Loss of functional A-type potassium channels in the dendrites of CA1 pyramidal neurons from a mouse model of fragile X syndrome.
Routh BN, Johnston D, Brager DH. Routh BN, et al. J Neurosci. 2013 Dec 11;33(50):19442-50. doi: 10.1523/JNEUROSCI.3256-13.2013. J Neurosci. 2013. PMID: 24336711 Free PMC article.
Despite the critical importance of voltage-gated ion channels in neurons, very little is known about their functional properties in Fragile X syndrome: the most common form of inherited cognitive impairment. ...These data suggest that loss of I(KA) in hippoca …
Despite the critical importance of voltage-gated ion channels in neurons, very little is known about their functional properties in Fragi …
Fragile X Mental Retardation Protein Bidirectionally Controls Dendritic Ih in a Cell Type-Specific Manner between Mouse Hippocampus and Prefrontal Cortex.
Brandalise F, Kalmbach BE, Mehta P, Thornton O, Johnston D, Zemelman BV, Brager DH. Brandalise F, et al. J Neurosci. 2020 Jul 1;40(27):5327-5340. doi: 10.1523/JNEUROSCI.1670-19.2020. Epub 2020 May 28. J Neurosci. 2020. PMID: 32467357 Free PMC article.
Channelopathies are implicated in Fragile X syndrome (FXS), yet the dysfunction of a particular ion channel varies with cell type. ...We, and others, previously identified cell type-specific channelopathies in a mouse of model of Fragile X sy …
Channelopathies are implicated in Fragile X syndrome (FXS), yet the dysfunction of a particular ion channel varies with …
Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome.
Leontiadis LJ, Trompoukis G, Tsotsokou G, Miliou A, Felemegkas P, Papatheodoropoulos C. Leontiadis LJ, et al. Front Cell Neurosci. 2023 Dec 1;17:1296235. doi: 10.3389/fncel.2023.1296235. eCollection 2023. Front Cell Neurosci. 2023. PMID: 38107412 Free PMC article.
Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder characterized by intellectual disability and is related to autism. ...We used a Fmr1 knock-out (KO) rat model of FXS and electrophysiological recordings from the CA1 area of adult rat hi …
Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder characterized by intellectual disability and is relat …
79 results